Editing The Total Synthesis Of Natural Products

<br>Cannabidiol-dimethylheptyl (CBD-DMH or DMH-CBD) is a synthetic homologue of cannabidiol where the pentyl chain has been replaced by a dimethylheptyl chain. Several isomers of this compound are known. The most commonly used isomer in research is (−)-[https://www.primabevallen.nl/contact/photo-1457342813143-a1ae27448a82 G.H. Farms CBD]-DMH, which has the same stereochemistry as natural cannabidiol, and a 1,1-dimethylheptyl side chain. This compound is not psychoactive and acts primarily as an anandamide reuptake inhibitor, but is more potent than cannabidiol as an anticonvulsant and has around the same potency as an antiinflammatory. Another closely analogous compound has also been described, with the double bond in the cyclohexene ring shifted to between the 1,6-positions rather than the 2,3-positions (i.e. analogous to synthetic THC analogues such as parahexyl), the isopropenyl group saturated to isopropyl, and a 1,2-dimethylheptyl side chain. It is synthesized by Birch reduction from the 1,2-dimethylheptyl analogue of cannabidiol. This compound also produces potent cannabinoid-like effects in animals, but has three chiral centers and is composed of a mixture of eight stereoisomers, which have not been [https://www.google.co.uk/search?hl=en&gl=us&tbm=nws&q=studied&gs_l=news studied] individually, so it is not known which stereoisomers are active.<br><br><br><br>Bisogno T, Hanus L, De Petrocellis L, Tchilibon S,  Try Global Health Farms Gummies Ponde DE, Brandi I, et al. October 2001). "Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide". British Journal of Pharmacology. 134 (4): 845-52. doi:10.1038/sj.bjp.0704327. Ben-Shabat S, Hanus LO, Katzavian G, Gallily R (February 2006). "New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity". Journal of Medicinal Chemistry. 49 (3): 1113-7. doi:10.1021/jm050709m. Juknat A, Kozela E, Kaushansky N, Mechoulam R, Vogel Z (May 2016). "Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia and encephalitogenic T cells". Journal of Basic and Clinical Physiology and Pharmacology. 27 (3): 289-96. doi:10.1515/jbcpp-2015-0071. Hanus LO, Tchilibon S, Ponde DE, Breuer A, Fride E, Mechoulam R (March 2005). "Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors". Organic & Biomolecular Chemistry. 3 (6): 1116-23. doi:10.1039/B416943C. Fride E, Ponde D, Breuer A, Hanus L (June 2005). "Peripheral, but not central effects of cannabidiol derivatives: mediation by CB(1) and unidentified receptors". Razdan RK, Pars HG, Thompson WR, Granchelli FE (1974). "Lithium-ammonia reduction of tetrahydrocannabinols". Razdan RK (1981). "The Total Synthesis of Cannabinoids". In Apsimon J (ed.). 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